AirHint found the following cheapest return flights from Panama City (PTY) to Santiago (SCL) in October 2025 (see full year).

Return flights

30 Oct - 05 Nov	Avianca
26 Oct - 29 Oct	Avianca
30 Oct - 15 Nov	Avianca
23 Oct - 27 Oct	Avianca
24 Oct - 18 Nov	Avianca
25 Oct - 29 Oct	Avianca
31 Oct - 05 Nov	Avianca
25 Oct - 27 Oct	Avianca
24 Oct - 18 Nov	Copa	direct
30 Oct - 05 Nov	Copa	direct
23 Oct - 27 Oct	Copa	direct
25 Oct - 27 Oct	Copa	direct
25 Oct - 29 Oct	Copa	direct
26 Oct - 29 Oct	Copa	direct
31 Oct - 05 Nov	Copa	direct

Also check the deals for one-way flights from Panama City to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Santiago in October from $543

Return flights