AirHint found the following cheapest return flights from Panama City (PTY) to Santiago (SCL) in August 2025 (see full year).

Return flights

27 Aug - 03 Sep	Avianca
23 Aug - 29 Aug	Copa	direct
15 Aug - 23 Aug	Copa	direct
15 Aug - 21 Aug	Copa	direct
14 Aug - 17 Aug	Copa	direct
11 Aug - 17 Aug	Copa	direct
27 Aug - 03 Sep	Copa	direct
05 Aug - 08 Aug	Copa	direct
07 Aug - 14 Aug	Copa	direct
01 Aug - 17 Aug	Avianca
01 Aug - 17 Aug	Copa	direct

Also check the deals for one-way flights from Panama City to Santiago in August.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Santiago in August from $467

Return flights