AirHint found the following cheapest return flights from Panama City (PTY) to Santiago (SCL) in September 2025 (see full year).

Return flights

17 Sep - 22 Sep	Copa	direct
30 Sep - 14 Oct	Copa	direct
23 Sep - 08 Oct	Copa	direct
02 Sep - 09 Sep	Avianca
10 Sep - 17 Sep	Avianca
03 Sep - 17 Sep	Avianca
10 Sep - 17 Sep	Copa	direct
22 Sep - 06 Oct	Copa	direct
22 Sep - 07 Oct	Copa	direct
21 Sep - 04 Oct	Avianca
05 Sep - 12 Sep	Avianca
11 Sep - 13 Sep	Avianca
06 Sep - 13 Sep	Avianca
03 Sep - 17 Sep	Copa	direct
21 Sep - 04 Oct	Copa	direct
11 Sep - 13 Sep	Copa	direct

Also check the deals for one-way flights from Panama City to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Santiago in September from $481

Return flights