AirHint found the following cheapest return flights from Panama City (PTY) to Quito (UIO) in December 2025 (see full year).

Return flights

18 Dec - 18 Jan	Avianca
30 Dec - 06 Jan	Copa	direct
13 Dec - 14 Dec	Avianca
14 Dec - 16 Dec	Avianca
18 Dec - 01 Jan	Avianca
26 Dec - 05 Jan	Avianca
12 Dec - 04 Jan	Avianca
14 Dec - 16 Dec	Copa	direct
12 Dec - 04 Jan	Copa	direct
13 Dec - 14 Dec	Copa	direct
18 Dec - 18 Jan	Copa	direct
18 Dec - 01 Jan	Copa	direct

Also check the deals for one-way flights from Panama City to Quito in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Quito in December from $424

Return flights