AirHint found the following cheapest return flights from Panama City (PTY) to Quito (UIO) in September 2025 (see full year).

Return flights

19 Sep - 08 Oct	Avianca
19 Sep - 23 Oct	Avianca
18 Sep - 08 Oct	Avianca
26 Sep - 04 Oct	Avianca
19 Sep - 26 Sep	Avianca
21 Sep - 28 Sep	Avianca
18 Sep - 25 Sep	Avianca
30 Sep - 12 Oct	Avianca
25 Sep - 29 Sep	Avianca
30 Sep - 12 Oct	Copa	direct
25 Sep - 29 Sep	Copa	direct
26 Sep - 04 Oct	Copa	direct
19 Sep - 26 Sep	Copa	direct
21 Sep - 28 Sep	Copa	direct
20 Sep - 27 Sep	Copa	direct
19 Sep - 08 Oct	Copa	direct
19 Sep - 23 Oct	Copa	direct
18 Sep - 25 Sep	Copa	direct
18 Sep - 08 Oct	Copa	direct

Also check the deals for one-way flights from Panama City to Quito in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Panama City to Quito in September from $434

Return flights