AirHint found the following cheapest return flights from Panama City (PTY) to Santa Cruz (VVI) in October 2025 (see full year).
Return flights
| 05 Oct - 09 Oct | Copa | direct | |
| 10 Oct - 12 Nov | Copa | direct | |
| 16 Oct - 20 Oct | Copa | direct |
Also check the deals for one-way flights from Panama City to Santa Cruz in October.
The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.
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