AirHint found the following cheapest return flights from Raleigh-durham (RDU) to Madrid (MAD) in September 2025 (see full year).

Return flights

19 Sep - 30 Sep	Air Canada
16 Sep - 23 Sep	Iberia
19 Sep - 26 Sep	United
22 Sep - 29 Sep	United
25 Sep - 02 Oct	United
20 Sep - 28 Sep	Air Canada
28 Sep - 05 Oct	Iberia
27 Sep - 04 Oct	jetBlue
10 Sep - 17 Sep	United
01 Sep - 08 Sep	United
07 Sep - 14 Sep	United
04 Sep - 11 Sep	United
13 Sep - 20 Sep	Iberia

Also check the deals for one-way flights from Raleigh-durham to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Raleigh-durham to Madrid in September from $606

Return flights