Cheapest return flights from Raleigh-durham to Rio Negro in October from $279

AirHint found the following cheapest return flights from Raleigh-durham (RDU) to Rio Negro (MDE) in October 2025 (see full year).

Return flights

06 Oct - 17 Oct Spirit Airlines
13 Oct - 17 Oct jetBlue
15 Oct - 22 Oct jetBlue
15 Oct - 04 Nov jetBlue
30 Oct - 03 Nov Spirit Airlines
01 Oct - 05 Oct Copa
01 Oct - 12 Oct Copa
09 Oct - 14 Oct Spirit Airlines
13 Oct - 03 Nov Spirit Airlines
30 Oct - 29 Nov LATAM Airlines Group

Also check the deals for one-way flights from Raleigh-durham to Rio Negro in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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