AirHint found the following cheapest return flights from Raleigh-durham (RDU) to Rio Negro (MDE) in November 2025 (see full year).
Return flights
| 19 Nov - 26 Nov | Copa | ||
| 14 Nov - 16 Nov | Copa | ||
| 19 Nov - 02 Dec | Copa | ||
| 25 Nov - 01 Dec | Frontier Airlines | ||
| 26 Nov - 01 Dec | Frontier Airlines |
Also check the deals for one-way flights from Raleigh-durham to Rio Negro in November.
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