Cheapest return flights from Raleigh-durham to Rio Negro in September from $261

AirHint found the following cheapest return flights from Raleigh-durham (RDU) to Rio Negro (MDE) in September 2025 (see full year).

Return flights

21 Sep - 06 Oct Spirit Airlines
25 Sep - 30 Sep American Airlines

Also check the deals for one-way flights from Raleigh-durham to Rio Negro in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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