AirHint found the following cheapest return flights from Rome (ROM) to Sao Paulo (GRU) in October 2025 (see full year).

Return flights

02 Oct - 14 Oct	TAP
13 Oct - 19 Oct	TAP
31 Oct - 07 Nov	TAP
13 Oct - 26 Oct	TAP
22 Oct - 29 Oct	TAP
06 Oct - 16 Oct	TAP
09 Oct - 13 Oct	TAP
12 Oct - 30 Oct	TAP
26 Oct - 13 Nov	TAP
28 Oct - 04 Nov	TAP
07 Oct - 07 Nov	TAP
19 Oct - 01 Nov	TAP
11 Oct - 14 Oct	TAP
27 Oct - 13 Nov	Lufthansa
20 Oct - 24 Oct	Air Europa
02 Oct - 04 Nov	British Airways
01 Oct - 12 Oct	British Airways
24 Oct - 03 Nov	Air Europa
24 Oct - 13 Nov	Air Europa
25 Oct - 14 Nov	Air Europa

Also check the deals for one-way flights from Rome to Sao Paulo in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Sao Paulo in October from $586

Return flights