AirHint found the following cheapest return flights from Rome (ROM) to Sao Paulo (GRU) in September 2025 (see full year).

Return flights

16 Sep - 16 Oct	TAP
11 Sep - 21 Sep	TAP
22 Sep - 09 Oct	TAP
22 Sep - 24 Oct	TAP
18 Sep - 31 Oct	TAP
25 Sep - 08 Oct	TAP
18 Sep - 30 Sep	TAP
19 Sep - 08 Oct	TAP
14 Sep - 06 Oct	TAP
25 Sep - 07 Oct	TAP
12 Sep - 20 Sep	TAP
17 Sep - 23 Sep	TAP
16 Sep - 29 Sep	TAP
05 Sep - 25 Sep	TAP
11 Sep - 25 Sep	TAP
29 Sep - 15 Oct	Ryanair
08 Sep - 21 Sep	Delta
08 Sep - 24 Sep	Delta
11 Sep - 22 Sep	Delta
30 Sep - 14 Oct	Wizz Air Malta

Also check the deals for one-way flights from Rome to Sao Paulo in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Sao Paulo in September from $687

Return flights