AirHint found the following cheapest return flights from Rome (ROM) to Panama City (PTY) in December 2025 (see full year).

Return flights

05 Dec - 26 Jan	Air Europa
12 Dec - 14 Dec	United
15 Dec - 11 Jan	Turkish Airlines
13 Dec - 12 Jan	Iberia
31 Dec - 10 Jan	Turkish Airlines
29 Dec - 11 Jan	Turkish Airlines
16 Dec - 11 Jan	Turkish Airlines
13 Dec - 09 Jan	Air France
19 Dec - 31 Dec	Turkish Airlines
18 Dec - 28 Dec	Air Europa
13 Dec - 10 Jan	Turkish Airlines
13 Dec - 07 Jan	Turkish Airlines
13 Dec - 06 Jan	Air France
21 Dec - 28 Dec	Air Europa
20 Dec - 28 Dec	Air Europa

Also check the deals for one-way flights from Rome to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Panama City in December from $758

Return flights