AirHint found the following cheapest return flights from Rome (ROM) to Santiago (SCL) in October 2025 (see full year).

Return flights

15 Oct - 11 Nov	Delta
24 Oct - 11 Nov	Delta
15 Oct - 28 Oct	Delta
01 Oct - 27 Oct	Delta
27 Oct - 16 Nov	Delta
17 Oct - 31 Oct	Delta
03 Oct - 16 Oct	Delta
10 Oct - 19 Oct	Delta
14 Oct - 11 Nov	Delta
01 Oct - 25 Oct	Delta

Also check the deals for one-way flights from Rome to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Santiago in October from $845

Return flights