AirHint found the following cheapest return flights from Rome (ROM) to Santiago (SCL) in December 2025 (see full year).

Return flights

01 Dec - 08 Dec	SWISS
07 Dec - 22 Jan	Delta
05 Dec - 08 Dec	Delta
05 Dec - 09 Dec	Delta
05 Dec - 12 Dec	Turkish Airlines
24 Dec - 16 Jan	Delta
11 Dec - 14 Dec	Turkish Airlines
24 Dec - 30 Dec	Delta
26 Dec - 31 Jan	Delta
09 Dec - 17 Jan	Delta
07 Dec - 15 Jan	Delta
08 Dec - 14 Dec	Delta
07 Dec - 13 Dec	Delta
07 Dec - 21 Dec	Delta
01 Dec - 18 Jan	Air Canada
10 Dec - 11 Jan	Delta
26 Dec - 16 Jan	Delta
01 Dec - 15 Dec	SWISS
25 Dec - 14 Jan	Delta
14 Dec - 18 Jan	Norse Atlantic Airways

Also check the deals for one-way flights from Rome to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Santiago in December from $866

Return flights