AirHint found the following cheapest return flights from Rome (ROM) to Santiago (SCL) in December 2025 (see full year).

Return flights

05 Dec - 08 Dec	Delta
05 Dec - 09 Dec	Delta
06 Dec - 22 Jan	Delta
09 Dec - 14 Jan	Delta
01 Dec - 10 Dec	SWISS
10 Dec - 16 Jan	Delta
04 Dec - 11 Dec	Turkish Airlines
24 Dec - 16 Jan	Delta
25 Dec - 14 Jan	Delta
09 Dec - 17 Jan	Delta
09 Dec - 15 Jan	Delta
10 Dec - 15 Jan	Delta
07 Dec - 15 Jan	Delta
04 Dec - 15 Dec	Delta
08 Dec - 12 Jan	Delta
06 Dec - 17 Dec	Delta
23 Dec - 30 Dec	Delta
05 Dec - 15 Dec	Air Europa
09 Dec - 31 Dec	Norse Atlantic Airways
15 Dec - 30 Dec	Delta

Also check the deals for one-way flights from Rome to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Santiago in December from $904

Return flights