AirHint found the following cheapest return flights from Rome (ROM) to Santiago (SCL) in December 2025 (see full year).

Return flights

01 Dec - 08 Dec	Air Canada
01 Dec - 31 Dec	Air Canada
09 Dec - 24 Dec	Air Canada
01 Dec - 22 Dec	Air Canada
30 Dec - 11 Jan	Turkish Airlines
30 Dec - 20 Jan	Turkish Airlines
08 Dec - 22 Jan	Delta
18 Dec - 28 Dec	Turkish Airlines
18 Dec - 10 Jan	Turkish Airlines
01 Dec - 04 Jan	Turkish Airlines
13 Dec - 06 Jan	Turkish Airlines
12 Dec - 06 Jan	Turkish Airlines
20 Dec - 17 Jan	Turkish Airlines
19 Dec - 09 Jan	Turkish Airlines
22 Dec - 04 Jan	Turkish Airlines

Also check the deals for one-way flights from Rome to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Santiago in December from $832

Return flights