AirHint found the following cheapest return flights from Rome (ROM) to Santiago (SCL) in December 2025 (see full year).

Return flights

27 Dec - 30 Dec	Delta
31 Dec - 22 Jan	Turkish Airlines
26 Dec - 30 Dec	Delta
28 Dec - 27 Jan	Delta
15 Dec - 18 Jan	Norse Atlantic Airways
23 Dec - 30 Dec	Delta
12 Dec - 15 Dec	Iberia
31 Dec - 15 Jan	Turkish Airlines
31 Dec - 16 Jan	Turkish Airlines
13 Dec - 19 Jan	TAP
31 Dec - 13 Jan	Turkish Airlines
29 Dec - 16 Jan	Delta
14 Dec - 19 Jan	Norse Atlantic Airways
15 Dec - 22 Dec	ITA Airways
13 Dec - 10 Jan	Norse Atlantic Airways
16 Dec - 23 Dec	Wizz Air Malta

Also check the deals for one-way flights from Rome to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Santiago in December from $1233

Return flights