AirHint found the following cheapest return flights from Rome (ROM) to Santiago (SCL) in December 2025 (see full year).

Return flights

01 Dec - 25 Jan	Iberia
06 Dec - 08 Dec	Delta
09 Dec - 31 Dec	Iberia
23 Dec - 30 Dec	Iberia
30 Dec - 13 Jan	Air Canada
29 Dec - 13 Jan	Air Canada
26 Dec - 14 Jan	Iberia
23 Dec - 16 Jan	Air Canada
23 Dec - 13 Jan	Air Canada
24 Dec - 30 Dec	Delta
22 Dec - 29 Dec	Iberia
07 Dec - 12 Jan	Ryanair
27 Dec - 14 Jan	Delta
24 Dec - 12 Jan	Iberia
24 Dec - 01 Jan	Iberia
15 Dec - 19 Dec	Norse Atlantic Airways
22 Dec - 28 Dec	Iberia
19 Dec - 29 Dec	Vueling Airlines
20 Dec - 31 Dec	Iberia
20 Dec - 23 Dec	Vueling Airlines

Also check the deals for one-way flights from Rome to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Santiago in December from $840

Return flights