AirHint found the following cheapest return flights from Rome (ROM) to Santiago (SCL) in September 2025 (see full year).

Return flights

15 Sep - 28 Sep	Delta
09 Sep - 22 Sep	Delta
09 Sep - 16 Sep	Delta
08 Sep - 22 Sep	Delta
25 Sep - 06 Oct	Delta
08 Sep - 25 Sep	Delta
08 Sep - 23 Sep	Delta
15 Sep - 12 Oct	Air France
16 Sep - 07 Oct	Delta
30 Sep - 04 Oct	Wizz Air Malta
12 Sep - 29 Sep	Transavia France
12 Sep - 28 Sep	Transavia France
05 Sep - 05 Oct	Delta
30 Sep - 08 Oct	Wizz Air Malta
07 Sep - 17 Oct	KLM
12 Sep - 19 Sep	TAP
05 Sep - 08 Sep	Delta
26 Sep - 07 Oct	Delta

Also check the deals for one-way flights from Rome to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Santiago in September from $834

Return flights