AirHint found the following cheapest return flights from San Diego (SAN) to Panama City (PTY) in May 2026 (see full year).

Return flights

05 May - 19 May	Frontier Airlines
15 May - 22 May	Copa	direct
17 May - 24 May	Copa	direct
18 May - 25 May	Copa	direct
20 May - 27 May	Copa	direct
08 May - 11 May	Copa	direct
20 May - 25 May	Copa	direct
15 May - 20 May	Copa	direct
04 May - 18 May	Copa	direct
06 May - 09 May	United
27 May - 28 Jun	United
27 May - 28 Jun	Copa	direct
26 May - 27 Jun	Alaska Airlines

Also check the deals for one-way flights from San Diego to Panama City in May.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from San Diego to Panama City in May from $505

Return flights