AirHint found the following cheapest return flights from Santiago (SCL) to Asuncion (ASU) in October 2025 (see full year).

Return flights

06 Oct - 09 Oct	JetSmart
06 Oct - 10 Oct	JetSmart
06 Oct - 18 Oct	JetSmart
07 Oct - 09 Oct	JetSmart
07 Oct - 10 Oct	JetSmart
07 Oct - 18 Oct	JetSmart
16 Oct - 18 Oct	JetSmart
16 Oct - 31 Oct	JetSmart
17 Oct - 18 Oct	JetSmart
17 Oct - 31 Oct	JetSmart
31 Oct - 16 Nov	JetSmart
31 Oct - 17 Nov	JetSmart
17 Oct - 06 Nov	JetSmart
31 Oct - 15 Nov	JetSmart
31 Oct - 06 Nov	JetSmart

Also check the deals for one-way flights from Santiago to Asuncion in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santiago to Asuncion in October from $280

Return flights