AirHint found the following cheapest return flights from Santiago (SCL) to Rome (FCO) in October 2025 (see full year).

Return flights

14 Oct - 13 Nov	British Airways
18 Oct - 14 Nov	LATAM Airlines Group
05 Oct - 23 Oct	British Airways
31 Oct - 07 Nov	LATAM Airlines Group
09 Oct - 26 Oct	Iberia
28 Oct - 10 Nov	Iberia
24 Oct - 31 Oct	Iberia
03 Oct - 24 Oct	Avianca
16 Oct - 31 Oct	Iberia
06 Oct - 29 Oct	Air France
20 Oct - 29 Oct	Iberia

Also check the deals for one-way flights from Santiago to Rome in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Rome

Cheap car rent in Rome

Cheapest return flights from Santiago to Rome in October from $1050

Return flights