AirHint found the following cheapest return flights from Santiago (SCL) to Rome (FCO) in September 2025 (see full year).

Return flights

23 Sep - 22 Oct	Sky Airline
24 Sep - 30 Sep	Avianca
20 Sep - 22 Oct	Avianca
29 Sep - 07 Oct	Avianca
27 Sep - 09 Oct	LATAM Airlines Group
28 Sep - 18 Oct	Sky Airline
27 Sep - 30 Oct	Avianca
20 Sep - 27 Sep	Avianca
28 Sep - 30 Oct	Sky Airline
18 Sep - 25 Sep	JetSmart
29 Sep - 04 Oct	Avianca
28 Sep - 05 Oct	LATAM Airlines Group
26 Sep - 03 Oct	LATAM Airlines Group
21 Sep - 28 Sep	Avianca
19 Sep - 27 Sep	Avianca

Also check the deals for one-way flights from Santiago to Rome in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santiago to Rome in September from $1089

Return flights