AirHint found the following cheapest return flights from Santiago (SCL) to Sao Paulo (GRU) in October 2025 (see full year).

Return flights

07 Oct - 17 Oct	LATAM Airlines Group
02 Oct - 11 Oct	Sky Airline	direct
22 Oct - 25 Oct	LATAM Airlines Group
17 Oct - 30 Oct	LATAM Airlines Group
03 Oct - 11 Oct	LATAM Airlines Group
09 Oct - 14 Oct	LATAM Airlines Group
13 Oct - 17 Oct	Sky Airline	direct
03 Oct - 19 Oct	LATAM Airlines Group	direct
16 Oct - 20 Oct	Sky Airline	direct
03 Oct - 11 Oct	Sky Airline	direct
30 Oct - 07 Nov	Sky Airline	direct
30 Oct - 03 Nov	Sky Airline	direct

Also check the deals for one-way flights from Santiago to Sao Paulo in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santiago to Sao Paulo in October from $231

Return flights