AirHint found the following cheapest return flights from Santiago (SCL) to Sao Paulo (GRU) in September 2025 (see full year).

Return flights

26 Sep - 27 Sep	JetSmart	direct
26 Sep - 28 Sep	JetSmart	direct
27 Sep - 28 Sep	JetSmart	direct
01 Sep - 09 Sep	JetSmart	direct
24 Sep - 27 Sep	JetSmart	direct
25 Sep - 27 Sep	JetSmart	direct
21 Sep - 27 Sep	JetSmart	direct
02 Sep - 09 Sep	JetSmart	direct
23 Sep - 27 Sep	JetSmart	direct
02 Sep - 07 Sep	JetSmart	direct
30 Sep - 02 Oct	JetSmart
29 Sep - 05 Oct	JetSmart
30 Sep - 08 Oct	JetSmart	direct
29 Sep - 05 Oct	LATAM Airlines Group	direct
30 Sep - 02 Oct	Sky Airline	direct

Also check the deals for one-way flights from Santiago to Sao Paulo in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santiago to Sao Paulo in September from $155

Return flights