Cheapest return flights from Santiago to Guayaquil in December from $421

AirHint found the following cheapest return flights from Santiago (SCL) to Guayaquil (GYE) in December 2025 (see full year).

Return flights

04 Dec - 11 Dec LATAM Airlines Group
07 Dec - 15 Dec LATAM Airlines Group
12 Dec - 18 Dec LATAM Airlines Group
05 Dec - 12 Dec LATAM Airlines Group
05 Dec - 08 Dec LATAM Airlines Group
13 Dec - 02 Jan LATAM Airlines Group
07 Dec - 15 Dec LATAM Airlines Group direct
14 Dec - 07 Jan LATAM Airlines Group
25 Dec - 07 Jan LATAM Airlines Group
24 Dec - 06 Jan LATAM Airlines Group
30 Dec - 19 Jan LATAM Airlines Group
27 Dec - 17 Jan LATAM Airlines Group
26 Dec - 11 Jan LATAM Airlines Group
25 Dec - 15 Jan LATAM Airlines Group
23 Dec - 13 Jan LATAM Airlines Group
18 Dec - 07 Jan LATAM Airlines Group
05 Dec - 09 Dec Copa
11 Dec - 16 Dec Copa
05 Dec - 08 Dec LATAM Airlines Group direct

Also check the deals for one-way flights from Santiago to Guayaquil in December.

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