AirHint found the following cheapest return flights from Santiago (SCL) to Guayaquil (GYE) in December 2025 (see full year).

Return flights

01 Dec - 15 Dec	Avianca
08 Dec - 17 Dec	LATAM Airlines Group
18 Dec - 06 Jan	LATAM Airlines Group
19 Dec - 28 Dec	LATAM Airlines Group
18 Dec - 07 Jan	LATAM Airlines Group
12 Dec - 18 Dec	LATAM Airlines Group
19 Dec - 12 Jan	LATAM Airlines Group
21 Dec - 18 Jan	LATAM Airlines Group
23 Dec - 11 Jan	LATAM Airlines Group
26 Dec - 11 Jan	LATAM Airlines Group
24 Dec - 13 Jan	Copa
16 Dec - 06 Jan	Copa
15 Dec - 08 Jan	Copa
21 Dec - 07 Jan	Copa

Also check the deals for one-way flights from Santiago to Guayaquil in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santiago to Guayaquil in December from $379

Return flights