Cheapest return flights from Santiago to Guayaquil in September from $312

AirHint found the following cheapest return flights from Santiago (SCL) to Guayaquil (GYE) in September 2025 (see full year).

Return flights

18 Sep - 25 Sep LATAM Airlines Group
07 Sep - 13 Sep Copa
03 Sep - 08 Sep Copa
08 Sep - 13 Sep Copa
15 Sep - 20 Sep LATAM Airlines Group
13 Sep - 20 Sep LATAM Airlines Group
25 Sep - 28 Sep Copa
12 Sep - 19 Sep LATAM Airlines Group
27 Sep - 06 Oct Copa
12 Sep - 20 Sep LATAM Airlines Group direct

Also check the deals for one-way flights from Santiago to Guayaquil in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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