Cheapest return flights from Santiago to Guayaquil in September from $395

AirHint found the following cheapest return flights from Santiago (SCL) to Guayaquil (GYE) in September 2025 (see full year).

Return flights

30 Sep - 30 Sep LATAM Airlines Group
20 Sep - 28 Sep Avianca
21 Sep - 30 Sep Avianca
18 Sep - 25 Sep LATAM Airlines Group
22 Sep - 25 Sep LATAM Airlines Group
08 Sep - 15 Sep LATAM Airlines Group
23 Sep - 15 Oct Sky Airline
08 Sep - 15 Sep LATAM Airlines Group direct
22 Sep - 26 Sep LATAM Airlines Group direct
19 Sep - 21 Sep Copa
09 Sep - 16 Sep Avianca

Also check the deals for one-way flights from Santiago to Guayaquil in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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