Cheapest return flights from Santiago to La Serena in December from $51

AirHint found the following cheapest return flights from Santiago (SCL) to La Serena (LSC) in December 2025 (see full year).

Return flights

06 Dec - 07 Dec LATAM Airlines Group direct
02 Dec - 06 Dec LATAM Airlines Group direct
07 Dec - 19 Dec JetSmart direct
07 Dec - 22 Dec JetSmart direct
22 Dec - 09 Jan JetSmart direct
05 Dec - 08 Dec LATAM Airlines Group direct
22 Dec - 05 Jan JetSmart direct
06 Dec - 19 Dec JetSmart direct
06 Dec - 22 Dec JetSmart direct

Also check the deals for one-way flights from Santiago to La Serena in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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