AirHint found the following cheapest return flights from Santiago (SCL) to Rio Negro (MDE) in September 2025 (see full year).

Return flights

24 Sep - 06 Oct	JetSmart
24 Sep - 13 Oct	JetSmart
24 Sep - 05 Oct	JetSmart
25 Sep - 29 Sep	LATAM Airlines Group
06 Sep - 13 Sep	LATAM Airlines Group
17 Sep - 06 Oct	JetSmart
17 Sep - 19 Sep	JetSmart
19 Sep - 06 Oct	JetSmart
16 Sep - 06 Oct	JetSmart
16 Sep - 19 Sep	JetSmart
10 Sep - 19 Sep	JetSmart
23 Sep - 24 Sep	LATAM Airlines Group
17 Sep - 05 Oct	JetSmart
19 Sep - 05 Oct	JetSmart
16 Sep - 05 Oct	JetSmart
25 Sep - 06 Oct	JetSmart
24 Sep - 28 Sep	JetSmart
20 Sep - 23 Sep	LATAM Airlines Group
17 Sep - 28 Sep	JetSmart
19 Sep - 28 Sep	JetSmart

Also check the deals for one-way flights from Santiago to Rio Negro in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santiago to Rio Negro in September from $344

Return flights