AirHint found the following cheapest return flights from Santiago (SCL) to Mexico City (MEX) in September 2025 (see full year).

Return flights

03 Sep - 11 Sep	Arajet
29 Sep - 14 Oct	Arajet
24 Sep - 14 Oct	Arajet
30 Sep - 14 Oct	Avianca
01 Sep - 25 Sep	Arajet
01 Sep - 14 Sep	Avianca
04 Sep - 11 Sep	Avianca
06 Sep - 25 Sep	Avianca
05 Sep - 28 Sep	Avianca
12 Sep - 12 Oct	Arajet
06 Sep - 28 Sep	Avianca
25 Sep - 02 Oct	Copa
22 Sep - 06 Oct	Copa
11 Sep - 24 Sep	LATAM Airlines Group
12 Sep - 18 Sep	Arajet
01 Sep - 07 Sep	Avianca
30 Sep - 14 Oct	LATAM Airlines Group	direct
27 Sep - 27 Oct	Copa
09 Sep - 03 Oct	Copa

Also check the deals for one-way flights from Santiago to Mexico City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santiago to Mexico City in September from $463

Return flights