Cheapest return flights from Santiago to Panama City in December from $640

Best time to book flights for Santiago (SCL) to Panama City (PTY) flights at AirHint

AirHint found the following cheapest return flights from Santiago (SCL) to Panama City (PTY) in December 2025 (see full year).

Return flights

15 Dec - 10 Jan Avianca
19 Dec - 02 Jan Avianca
01 Dec - 19 Dec LATAM Airlines Group
02 Dec - 11 Dec Copa direct
01 Dec - 19 Dec Copa direct
02 Dec - 01 Jan Copa direct
01 Dec - 01 Jan Copa direct
27 Dec - 04 Jan Copa direct
19 Dec - 02 Jan Copa direct
15 Dec - 10 Jan Copa direct

Also check the deals for one-way flights from Santiago to Panama City in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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