AirHint found the following cheapest return flights from Santiago (SCL) to Quito (UIO) in October 2025 (see full year).

Return flights

29 Oct - 05 Nov	JetSmart
29 Oct - 31 Oct	JetSmart
29 Oct - 14 Nov	JetSmart
29 Oct - 16 Nov	JetSmart
19 Oct - 05 Nov	JetSmart
19 Oct - 31 Oct	JetSmart
09 Oct - 16 Oct	Avianca
17 Oct - 05 Nov	JetSmart
17 Oct - 31 Oct	JetSmart

Also check the deals for one-way flights from Santiago to Quito in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santiago to Quito in October from $355

Return flights