AirHint found the following cheapest return flights from Santiago (SCL) to Quito (UIO) in December 2025 (see full year).

Return flights

10 Dec - 24 Dec	JetSmart
07 Dec - 24 Dec	JetSmart
28 Dec - 16 Jan	JetSmart
31 Dec - 16 Jan	JetSmart
10 Dec - 21 Dec	JetSmart
07 Dec - 21 Dec	JetSmart
31 Dec - 18 Jan	JetSmart
18 Dec - 30 Dec	LATAM Airlines Group
19 Dec - 30 Dec	LATAM Airlines Group
22 Dec - 12 Jan	LATAM Airlines Group
19 Dec - 03 Jan	LATAM Airlines Group

Also check the deals for one-way flights from Santiago to Quito in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Quito

Cheap car rent in Quito

Cheapest return flights from Santiago to Quito in December from $394

Return flights