AirHint found the following cheapest return flights from Santiago (SCL) to Quito (UIO) in September 2025 (see full year).

Return flights

10 Sep - 14 Sep	JetSmart
07 Sep - 14 Sep	JetSmart
07 Sep - 10 Sep	JetSmart
10 Sep - 24 Sep	JetSmart
17 Sep - 01 Oct	JetSmart
17 Sep - 05 Oct	JetSmart
07 Sep - 24 Sep	JetSmart
01 Sep - 11 Sep	Avianca
21 Sep - 01 Oct	JetSmart
21 Sep - 05 Oct	JetSmart
17 Sep - 24 Sep	JetSmart
21 Sep - 24 Sep	JetSmart
14 Sep - 01 Oct	JetSmart
12 Sep - 14 Sep	JetSmart
14 Sep - 24 Sep	JetSmart
12 Sep - 01 Oct	JetSmart

Also check the deals for one-way flights from Santiago to Quito in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santiago to Quito in September from $370

Return flights