AirHint found the following cheapest return flights from Santiago (SCQ) to Rome (FCO) in October 2025 (see full year).

Return flights

07 Oct - 14 Oct	Ryanair
03 Oct - 07 Oct	Iberia
17 Oct - 21 Oct	Iberia
18 Oct - 21 Oct	Iberia
04 Oct - 07 Oct	Vueling Airlines
03 Oct - 08 Oct	Iberia
24 Oct - 26 Oct	Iberia
22 Oct - 28 Oct	Ryanair
03 Oct - 05 Oct	Iberia
25 Oct - 31 Oct	Iberia
22 Oct - 11 Nov	Vueling Airlines
30 Oct - 03 Nov	Ryanair
31 Oct - 03 Nov	Ryanair
24 Oct - 11 Nov	Vueling Airlines
31 Oct - 02 Nov	Ryanair
25 Oct - 11 Nov	Vueling Airlines
22 Oct - 08 Nov	Vueling Airlines
22 Oct - 10 Nov	Vueling Airlines
22 Oct - 07 Nov	Vueling Airlines
22 Oct - 05 Nov	Vueling Airlines

Also check the deals for one-way flights from Santiago to Rome in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santiago to Rome in October from $119

Return flights