AirHint found the following cheapest return flights from Santiago (SCQ) to Prague (PRG) in December 2025 (see full year).

Return flights

31 Dec - 05 Jan	Ryanair
24 Dec - 11 Jan	Iberia
31 Dec - 04 Jan	Ryanair
25 Dec - 02 Jan	Iberia
22 Dec - 25 Dec	Iberia
27 Dec - 31 Dec	Iberia
25 Dec - 28 Dec	Iberia
27 Dec - 30 Dec	Iberia
27 Dec - 09 Jan	Vueling Airlines
26 Dec - 02 Jan	Ryanair
22 Dec - 27 Dec	Iberia
26 Dec - 09 Jan	Vueling Airlines
22 Dec - 09 Jan	Vueling Airlines
26 Dec - 28 Dec	Ryanair
27 Dec - 05 Jan	Vueling Airlines
27 Dec - 11 Jan	Vueling Airlines
26 Dec - 29 Dec	Ryanair
26 Dec - 27 Dec	Vueling Airlines
22 Dec - 26 Dec	Vueling Airlines
22 Dec - 30 Dec	Vueling Airlines

Also check the deals for one-way flights from Santiago to Prague in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santiago to Prague in December from $200

Return flights