AirHint found the following cheapest return flights from Santo Domingo (SDQ) to Madrid (MAD) in October 2025 (see full year).

Return flights

07 Oct - 14 Oct	Arajet
07 Oct - 22 Oct	Arajet
27 Oct - 03 Nov	Arajet
07 Oct - 21 Oct	Arajet
05 Oct - 19 Oct	Arajet
06 Oct - 02 Nov	Arajet
02 Oct - 26 Oct	WORLD2FLY	direct
02 Oct - 16 Oct	WORLD2FLY	direct
01 Oct - 26 Oct	Arajet
01 Oct - 19 Oct	Iberia	direct
07 Oct - 14 Oct	Iberia	direct
07 Oct - 22 Oct	Air Europa	direct
28 Oct - 05 Nov	Air Europa	direct
27 Oct - 03 Nov	Iberia	direct
06 Oct - 02 Nov	Iberia	direct
15 Oct - 02 Nov	Air Europa	direct

Also check the deals for one-way flights from Santo Domingo to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santo Domingo to Madrid in October from $600

Return flights