AirHint found the following cheapest return flights from Santo Domingo (SDQ) to Madrid (MAD) in October 2025 (see full year).

Return flights

12 Oct - 26 Oct	WORLD2FLY	direct
16 Oct - 26 Oct	WORLD2FLY	direct
17 Oct - 26 Oct	Arajet
09 Oct - 23 Oct	WORLD2FLY	direct
05 Oct - 19 Oct	Arajet
04 Oct - 19 Oct	Arajet
09 Oct - 06 Nov	WORLD2FLY	direct
21 Oct - 01 Nov	Iberia	direct
01 Oct - 26 Oct	Arajet
02 Oct - 23 Oct	Spirit Airlines
09 Oct - 24 Oct	Iberia	direct
18 Oct - 22 Nov	Spirit Airlines
17 Oct - 26 Oct	Air Europa	direct
02 Oct - 06 Nov	Air Europa	direct
21 Oct - 11 Nov	Air Europa	direct
24 Oct - 10 Nov	Air Europa	direct
15 Oct - 02 Nov	Air Europa	direct

Also check the deals for one-way flights from Santo Domingo to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santo Domingo to Madrid in October from $684

Return flights