AirHint found the following cheapest return flights from Santo Domingo (SDQ) to Panama City (PTY) in December 2025 (see full year).

Return flights

25 Dec - 31 Dec	Avianca
22 Dec - 21 Jan	Spirit Airlines
28 Dec - 05 Jan	Copa	direct
14 Dec - 17 Dec	Frontier Airlines
17 Dec - 24 Dec	Arajet
23 Dec - 11 Jan	Copa	direct
25 Dec - 02 Jan	Copa	direct
22 Dec - 21 Jan	Copa	direct
24 Dec - 04 Jan	Copa	direct
31 Dec - 31 Dec	Arajet
18 Dec - 25 Dec	Copa	direct
25 Dec - 31 Dec	Copa	direct
18 Dec - 11 Jan	Copa	direct
18 Dec - 08 Jan	Copa	direct
17 Dec - 24 Dec	Copa	direct
31 Dec - 31 Dec	Copa	direct
14 Dec - 17 Dec	Copa	direct
19 Dec - 04 Jan	Arajet
19 Dec - 04 Jan	Copa	direct

Also check the deals for one-way flights from Santo Domingo to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santo Domingo to Panama City in December from $525

Return flights