AirHint found the following cheapest return flights from Santander (SDR) to Manchester (MAN) in October 2025 (see full year).

Return flights

16 Oct - 23 Oct	Ryanair	direct
09 Oct - 23 Oct	Ryanair	direct
19 Oct - 23 Oct	Ryanair	direct
16 Oct - 19 Oct	Ryanair	direct
09 Oct - 12 Oct	Ryanair	direct
09 Oct - 19 Oct	Ryanair	direct
12 Oct - 23 Oct	Ryanair	direct
12 Oct - 19 Oct	Ryanair	direct
02 Oct - 23 Oct	Ryanair	direct
02 Oct - 12 Oct	Ryanair	direct
16 Oct - 02 Nov	Ryanair
19 Oct - 02 Nov	Ryanair
23 Oct - 02 Nov	Ryanair
25 Oct - 02 Nov	Vueling Airlines
18 Oct - 02 Nov	Vueling Airlines
12 Oct - 02 Nov	Ryanair

Also check the deals for one-way flights from Santander to Manchester in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santander to Manchester in October from $48

Return flights