AirHint found the following cheapest return flights from Santander (SDR) to Prague (PRG) in October 2025 (see full year).

Return flights

18 Oct - 22 Oct	Ryanair
18 Oct - 21 Oct	Ryanair
15 Oct - 18 Oct	Ryanair
17 Oct - 21 Oct	Ryanair
22 Oct - 25 Oct	Vueling Airlines
10 Oct - 13 Oct	Ryanair
16 Oct - 20 Oct	Vueling Airlines
22 Oct - 29 Oct	Vueling Airlines
06 Oct - 12 Oct	Ryanair
06 Oct - 21 Oct	Vueling Airlines

Also check the deals for one-way flights from Santander to Prague in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santander to Prague in October from $150

Return flights