AirHint found the following cheapest return flights from Santander (SDR) to Prague (PRG) in December 2025 (see full year).

Return flights

01 Dec - 05 Dec	Ryanair
01 Dec - 06 Dec	Ryanair
01 Dec - 03 Dec	Ryanair
06 Dec - 12 Dec	Ryanair
06 Dec - 07 Dec	Ryanair
23 Dec - 30 Dec	Ryanair
02 Dec - 06 Dec	Ryanair
30 Dec - 05 Jan	Ryanair
13 Dec - 15 Dec	Ryanair
01 Dec - 04 Dec	Ryanair
29 Dec - 05 Jan	Ryanair
30 Dec - 06 Jan	Ryanair
05 Dec - 07 Dec	Vueling Airlines
30 Dec - 04 Jan	Ryanair
29 Dec - 04 Jan	Ryanair
26 Dec - 04 Jan	Ryanair
27 Dec - 04 Jan	Ryanair
27 Dec - 03 Jan	Ryanair

Also check the deals for one-way flights from Santander to Prague in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santander to Prague in December from $199

Return flights