AirHint found the following cheapest return flights from Santander (SDR) to Prague (PRG) in September 2025 (see full year).

Return flights

17 Sep - 24 Sep	Ryanair
18 Sep - 22 Sep	Ryanair
10 Sep - 17 Sep	Ryanair
26 Sep - 02 Oct	Ryanair
19 Sep - 22 Sep	Ryanair
13 Sep - 17 Sep	Ryanair
10 Sep - 13 Sep	Ryanair
26 Sep - 30 Sep	Ryanair
14 Sep - 20 Sep	Ryanair
26 Sep - 28 Sep	Ryanair
26 Sep - 05 Oct	Ryanair
19 Sep - 21 Sep	Ryanair
26 Sep - 12 Oct	Ryanair
25 Sep - 12 Oct	Ryanair
22 Sep - 12 Oct	Vueling Airlines
27 Sep - 12 Oct	Vueling Airlines
17 Sep - 05 Oct	Vueling Airlines
25 Sep - 05 Oct	Vueling Airlines
19 Sep - 05 Oct	Vueling Airlines
22 Sep - 05 Oct	Vueling Airlines

Also check the deals for one-way flights from Santander to Prague in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santander to Prague in September from $153

Return flights