AirHint found the following cheapest return flights from San Francisco (SFO) to Sao Paulo (GRU) in October 2025 (see full year).

Return flights

13 Oct - 21 Oct	Copa
09 Oct - 27 Oct	Copa
07 Oct - 16 Oct	Copa
08 Oct - 16 Oct	Copa
02 Oct - 20 Oct	Copa
09 Oct - 26 Oct	LATAM Airlines Group
10 Oct - 26 Oct	LATAM Airlines Group
03 Oct - 20 Oct	Copa
08 Oct - 11 Oct	LATAM Airlines Group
03 Oct - 17 Oct	Delta

Also check the deals for one-way flights from San Francisco to Sao Paulo in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from San Francisco to Sao Paulo in October from $622

Return flights