AirHint found the following cheapest return flights from San Francisco (SFO) to Guatemala City (GUA) in October 2025 (see full year).

Return flights

27 Oct - 10 Nov	Frontier Airlines
10 Oct - 14 Oct	Frontier Airlines
30 Oct - 06 Nov	Frontier Airlines
14 Oct - 20 Oct	jetBlue
14 Oct - 19 Oct	Frontier Airlines
15 Oct - 20 Oct	Frontier Airlines
03 Oct - 07 Oct	Frontier Airlines
03 Oct - 08 Oct	Frontier Airlines
03 Oct - 06 Oct	Frontier Airlines
03 Oct - 09 Oct	Frontier Airlines
04 Oct - 09 Oct	Frontier Airlines
25 Oct - 22 Nov	jetBlue

Also check the deals for one-way flights from San Francisco to Guatemala City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from San Francisco to Guatemala City in October from $305

Return flights