AirHint found the following cheapest return flights from San Francisco (SFO) to Prague (PRG) in October 2025 (see full year).

Return flights

29 Oct - 12 Nov	Scandinavian Airlines
09 Oct - 23 Oct	Condor
02 Oct - 16 Oct	Condor
09 Oct - 30 Oct	Scandinavian Airlines
16 Oct - 30 Oct	Scandinavian Airlines
01 Oct - 06 Oct	Condor
09 Oct - 27 Oct	Scandinavian Airlines
16 Oct - 31 Oct	Scandinavian Airlines
09 Oct - 25 Oct	Condor

Also check the deals for one-way flights from San Francisco to Prague in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Prague

Cheap car rent in Prague

Cheapest return flights from San Francisco to Prague in October from $434

Return flights