AirHint found the following cheapest return flights from San Francisco (SFO) to Prague (PRG) in October 2025 (see full year).

Return flights

21 Oct - 03 Nov	Scandinavian Airlines
23 Oct - 15 Nov	Scandinavian Airlines
23 Oct - 06 Nov	Scandinavian Airlines
13 Oct - 20 Oct	Scandinavian Airlines
25 Oct - 05 Nov	Scandinavian Airlines
13 Oct - 29 Oct	Condor
14 Oct - 21 Oct	Condor
12 Oct - 22 Oct	Scandinavian Airlines
22 Oct - 28 Oct	Condor
22 Oct - 15 Nov	Scandinavian Airlines
26 Oct - 09 Nov	Scandinavian Airlines
09 Oct - 14 Oct	Condor
01 Oct - 15 Oct	Condor
07 Oct - 14 Oct	SWISS
08 Oct - 15 Oct	SWISS
01 Oct - 25 Oct	Condor

Also check the deals for one-way flights from San Francisco to Prague in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from San Francisco to Prague in October from $426

Return flights