AirHint found the following cheapest return flights from San Francisco (SFO) to Prague (PRG) in September 2025 (see full year).

Return flights

24 Sep - 08 Oct	Condor
09 Sep - 16 Sep	SWISS
16 Sep - 23 Sep	SWISS
24 Sep - 01 Oct	SWISS
30 Sep - 07 Oct	SWISS
09 Sep - 04 Oct	Air Canada
14 Sep - 21 Sep	SWISS
24 Sep - 18 Oct	SWISS
29 Sep - 06 Oct	SWISS
15 Sep - 22 Sep	SWISS
23 Sep - 28 Sep	Turkish Airlines
11 Sep - 04 Oct	Hawaiian Airlines
10 Sep - 13 Sep	Condor
13 Sep - 20 Sep	SWISS
11 Sep - 18 Sep	SWISS
11 Sep - 14 Sep	Condor
12 Sep - 19 Sep	Lufthansa
17 Sep - 11 Oct	Condor
25 Sep - 11 Oct	Frontier Airlines
27 Sep - 04 Oct	SWISS

Also check the deals for one-way flights from San Francisco to Prague in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from San Francisco to Prague in September from $480

Return flights