AirHint found the following cheapest return flights from San Francisco (SFO) to Panama City (PTY) in December 2025 (see full year).

Return flights

09 Dec - 30 Dec	United
08 Dec - 30 Dec	United
09 Dec - 30 Dec	Copa	direct
08 Dec - 30 Dec	Copa	direct
17 Dec - 03 Jan	Sun Country Airlines
18 Dec - 03 Jan	Alaska Airlines
17 Dec - 03 Jan	Copa	direct
18 Dec - 03 Jan	Copa	direct

Also check the deals for one-way flights from San Francisco to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from San Francisco to Panama City in December from $661

Return flights