Cheapest return flights from San Francisco to Panama City in December from $1059

Best time to book flights for San Francisco (SFO) to Panama City (PTY) flights at AirHint

AirHint found the following cheapest return flights from San Francisco (SFO) to Panama City (PTY) in December 2025 (see full year).

Return flights

17 Dec - 07 Jan Avianca
25 Dec - 01 Jan Alaska Airlines
17 Dec - 07 Jan Copa direct
22 Dec - 05 Jan American Airlines
25 Dec - 01 Jan United direct
26 Dec - 02 Jan American Airlines
26 Dec - 02 Jan United direct
22 Dec - 05 Jan Copa direct

Also check the deals for one-way flights from San Francisco to Panama City in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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