AirHint found the following cheapest return flights from San Francisco (SFO) to Panama City (PTY) in December 2025 (see full year).

Return flights

07 Dec - 15 Dec	Avianca
09 Dec - 15 Dec	Hawaiian Airlines
08 Dec - 14 Dec	Frontier Airlines
09 Dec - 29 Dec	Hawaiian Airlines
08 Dec - 14 Dec	Copa	direct
28 Dec - 19 Jan	Frontier Airlines
08 Dec - 30 Dec	American Airlines
07 Dec - 15 Dec	United	direct
28 Dec - 19 Jan	Copa	direct
09 Dec - 15 Dec	Copa	direct
08 Dec - 30 Dec	Copa	direct
24 Dec - 15 Jan	United
25 Dec - 15 Jan	United
24 Dec - 31 Dec	Alaska Airlines
24 Dec - 15 Jan	Copa	direct
25 Dec - 15 Jan	Copa	direct
21 Dec - 01 Jan	Frontier Airlines
19 Dec - 09 Jan	Frontier Airlines
28 Dec - 04 Jan	Frontier Airlines
28 Dec - 01 Jan	United

Also check the deals for one-way flights from San Francisco to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from San Francisco to Panama City in December from $557

Return flights