AirHint found the following cheapest return flights from San Francisco (SFO) to Santiago (SCL) in December 2025 (see full year).

Return flights

11 Dec - 18 Dec	United
02 Dec - 06 Dec	LATAM Airlines Group
14 Dec - 24 Dec	Delta
12 Dec - 27 Dec	American Airlines
16 Dec - 25 Dec	Copa
12 Dec - 09 Jan	Frontier Airlines
10 Dec - 07 Jan	Hawaiian Airlines
14 Dec - 08 Jan	Frontier Airlines
17 Dec - 24 Dec	LATAM Airlines Group
14 Dec - 09 Jan	Frontier Airlines
10 Dec - 04 Jan	Hawaiian Airlines
22 Dec - 12 Jan	LATAM Airlines Group
11 Dec - 06 Jan	Frontier Airlines
18 Dec - 10 Jan	Frontier Airlines
25 Dec - 01 Jan	LATAM Airlines Group
12 Dec - 03 Jan	Frontier Airlines

Also check the deals for one-way flights from San Francisco to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from San Francisco to Santiago in December from $495

Return flights