AirHint found the following cheapest return flights from Tampa (TPA) to Santiago (SCL) in October 2025 (see full year).

Return flights

01 Oct - 08 Oct	Copa
08 Oct - 15 Oct	Copa
15 Oct - 29 Oct	Copa
15 Oct - 22 Oct	Copa
03 Oct - 10 Oct	Copa
10 Oct - 17 Oct	Copa
29 Oct - 05 Nov	Copa
05 Oct - 12 Oct	Copa
12 Oct - 19 Oct	Copa
19 Oct - 26 Oct	Copa
02 Oct - 09 Oct	LATAM Airlines Group
25 Oct - 01 Nov	United
26 Oct - 02 Nov	LATAM Airlines Group
27 Oct - 03 Nov	LATAM Airlines Group
28 Oct - 04 Nov	LATAM Airlines Group
30 Oct - 06 Nov	LATAM Airlines Group
31 Oct - 07 Nov	LATAM Airlines Group

Also check the deals for one-way flights from Tampa to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago

Cheapest return flights from Tampa to Santiago in October from $447

Return flights