AirHint found the following cheapest return flights from Tampa (TPA) to Santiago (SCL) in September 2025 (see full year).

Return flights

01 Sep - 08 Sep	Copa
02 Sep - 09 Sep	Copa
03 Sep - 10 Sep	Copa
12 Sep - 19 Sep	Copa
17 Sep - 24 Sep	Copa
24 Sep - 01 Oct	Copa
10 Sep - 17 Sep	Copa
14 Sep - 21 Sep	Copa
28 Sep - 05 Oct	Copa
08 Sep - 15 Sep	LATAM Airlines Group
09 Sep - 16 Sep	LATAM Airlines Group
11 Sep - 18 Sep	LATAM Airlines Group
25 Sep - 02 Oct	LATAM Airlines Group
26 Sep - 03 Oct	LATAM Airlines Group
29 Sep - 06 Oct	LATAM Airlines Group
30 Sep - 07 Oct	LATAM Airlines Group
27 Sep - 04 Oct	Copa

Also check the deals for one-way flights from Tampa to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Tampa to Santiago in September from $447

Return flights