Cheapest return flights from Knoxville to Chicago in September from $85

AirHint found the following cheapest return flights from Knoxville (TYS) to Chicago (MDW) in September 2025 (see full year).

Return flights

12 Sep - 15 Sep Allegiant Air direct
26 Sep - 03 Oct Allegiant Air direct
15 Sep - 03 Oct Allegiant Air direct
08 Sep - 15 Sep Allegiant Air direct
12 Sep - 03 Oct Allegiant Air direct
08 Sep - 19 Sep Allegiant Air direct
26 Sep - 06 Oct Allegiant Air direct
15 Sep - 06 Oct Allegiant Air direct
29 Sep - 03 Oct Allegiant Air direct
26 Sep - 17 Oct Allegiant Air direct
29 Sep - 06 Oct Allegiant Air direct
29 Sep - 17 Oct Allegiant Air direct
09 Sep - 16 Sep Delta
10 Sep - 14 Sep Delta
23 Sep - 24 Sep Delta
25 Sep - 26 Sep Delta

Also check the deals for one-way flights from Knoxville to Chicago in September.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Chicago

Cheap car rent in Chicago

Feel free to contact us with any feedback or request another flight research.