AirHint found the following cheapest return flights from Quito (UIO) to Madrid (MAD) in December 2025 (see full year).

Return flights

24 Dec - 13 Jan	Iberia	direct
23 Dec - 17 Jan	Air Europa	direct
23 Dec - 01 Jan	Air Europa	direct
23 Dec - 13 Jan	Air Europa	direct
07 Dec - 13 Jan	Iberia	direct
23 Dec - 19 Jan	Iberia	direct
23 Dec - 18 Jan	Iberia	direct
24 Dec - 31 Jan	Air France
24 Dec - 31 Dec	LATAM Airlines Group
25 Dec - 10 Jan	Air Europa	direct
09 Dec - 10 Jan	Air Europa	direct
01 Dec - 31 Dec	Avianca
24 Dec - 31 Dec	Iberia	direct
01 Dec - 07 Dec	Iberia
05 Dec - 12 Dec	Avianca
02 Dec - 07 Dec	Iberia
03 Dec - 10 Dec	Iberia
08 Dec - 29 Dec	Avianca
04 Dec - 14 Dec	Avianca
09 Dec - 13 Dec	Air Europa

Also check the deals for one-way flights from Quito to Madrid in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Madrid in December from $768

Return flights