AirHint found the following cheapest return flights from Quito (UIO) to Madrid (MAD) in September 2025 (see full year).

Return flights

24 Sep - 29 Sep	Avianca
09 Sep - 25 Sep	Avianca
22 Sep - 26 Oct	Avianca
17 Sep - 24 Sep	Avianca
19 Sep - 18 Oct	Avianca
17 Sep - 24 Sep	Air Europa	direct
14 Sep - 14 Oct	LATAM Airlines Group
09 Sep - 27 Sep	Avianca
02 Sep - 30 Sep	LATAM Airlines Group
23 Sep - 08 Oct	LATAM Airlines Group
04 Sep - 30 Sep	Avianca
08 Sep - 21 Sep	LATAM Airlines Group
07 Sep - 14 Sep	Avianca
05 Sep - 30 Sep	Avianca
14 Sep - 14 Oct	Air Europa	direct
11 Sep - 01 Oct	Avianca
04 Sep - 10 Oct	Avianca
05 Sep - 10 Oct	Avianca
24 Sep - 08 Oct	Avianca
19 Sep - 19 Oct	Avianca

Also check the deals for one-way flights from Quito to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Quito to Madrid in September from $791

Return flights